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 Senator Susan Collins, a Republican from Maine who has been the subject of threats and had a window broken at her home, said in a statement that she “was horrified by this vicious attack on Paul Pelosi at his home.” She recentat she would not be surprised if a lawmaker were killed, given the environment of escalating threats.

Speaking at a political event in Pennsylvania, President Biden said on Friday that he had spoken to Ms. Pelosi to “send our love,” and that she relayed that her husband was “coming along well.”

“There’s too much violence,” President Biden said. “Political violence. Too much hatred. Too much vitriol. And what makes us think that one party can talk about stolen elections, Covid being a hoax, it’s all a bunch of lies, and it not affect people who may not be so well balanced?”

Not every elected leader reacted to the brutal attack on Mr. Pelosi in a solemn tone. At a political rally on Friday, Gov. Glenn Youngkin of Virginia, a Republican, seemed to minimize the attack on Mr. Pelosi, saying, “There’s no room for violence anywhere, but we’re going to send her back to be with him in California.”

For San Francisco, the break-in and assault comes at a time when the city is awash in crises over crime and disorder in the streets, where open-air drug dealing is commonplace and concerns over burglaries, especially in wealthy neighborhoods, helped fuel the successful recall of the city’s avowed progressive district attorney, Chesa Boudin, this year.

For the Pelosis, Friday’s incident was not the first time their home had become a crime scene. Since 1987, the couple has owned a three-story red brick house in the Pacific Heights neighborhood, and in January 2021, after Congress passed a stimulus bill, their residence waand a pig’s head was left on the sidewalk.

Mr. Pelosi, a real estate and technology investor, met Ms. Pelosi in Washington while he was studying at Georgetown University, and the couple married in 1963. A spokesman for the speaker, who rushed back to San Francisco on Friday and arrived at the hospital in the afternoon, said in a statement that Mr. Pelosi was “receiving excellent medical care” at the hospital.

Multiple law enforcement agencies were investigating the attack on Friday to determine the suspect’s motive. The Capitol Police said special agents from its field office in California “quickly arrived on the scene” to work alongside the F.B.I., the San Francisco Police Department, the district attorney and the U.S. attorney’s office.

It was Mr. Pelosi who surreptitiously called 911 from the bathroom while the assailant was in the house, bringing the police to the scene and potentially saving his life, Ms. Jenkins said.

Ms. Jenkins said a quick-thinking emergency dispatcher alerted the police while having “to interpret the situation based on some things that he said,” and inferring that “there was something amiss.”

As threats against lawmakers have skyrocketed in recent years, few have faced the level of vitriol that Ms. Pelosi has. The speaker has been demonized for years by people on the right, and with increasing ferocity.